| Security Name | Ticker | % of Net Assets |
|---|---|---|
| ABBVIE INC | ABBV | 7.33% |
| AMGEN INC. | AMGN | 4.91% |
| VERTEX PHARMACEUTICALS | VRTX | 4.41% |
| GILEAD SCIENCES, INC. | GILD | 4.37% |
| REGENERON PHARMACEUTICALS | REGN | 3.65% |
| ALNYLAM PHARMACEUTICALS | ALNY | 2.93% |
| NATERA INC | NTRA | 2.37% |
| INSMED INC | INSM | 2.36% |
| ASTRAZENECA PLC ADR | AZN | 2.23% |
| BEONE MEDICINES LTD-ADR | BGNE | 2.19% |
| BIOGEN IDEC, INC. | BIIB | 2.09% |
| ILLUMINA INC | ILMN | 1.93% |
| ROYALTY PHARMA PLC- CL A | RPRX | 1.89% |
| UNITED THERAPEUTICS CORP | UTHR | 1.88% |
| EXACT SCIENCES | EXAS | 1.79% |
| INCYTE CORP | INCY | 1.73% |
| VIATRIS INC | VTRS | 1.61% |
| REVOLUTION MEDICINES INC | RVMD | 1.55% |
| GUARDANT HEALTH INC | GH | 1.47% |
| MODERNA INC | MRNA | 1.46% |
| BIOMARIN PHARMACEUTICAL | BMRN | 1.45% |
| BRIDGEBIO PHARMA INC | BBIO | 1.44% |
| IONIS PHARMACEUTICALS, IN | IONS | 1.43% |
| NEUROCRINE BIOSCIENCES IN | NBIX | 1.42% |
| JAZZ PHARMACEUTICALS PLC | JAZZ | 1.39% |
| EXELIXIS, INC. | EXEL | 1.38% |
| ARGENX SE - ADR | ARGX | 1.37% |
| AVIDITY BIOSCIENCES INC | RNA | 1.33% |
| HALOZYME THERAPEUTICS INC | HALO | 1.28% |
| MEDPACE HOLDINGS | MEDP | 1.24% |
| CRISPR THERAPEUTICS AG | CRSP | 1.21% |
| ROIVANT SCIENCES LTD | ROIV | 1.21% |
| BIONTECH SE-ADR | BNTX | 1.14% |
| CYTOKINETICS INC | CYTK | 1.13% |
| ALKERMES PLC | ALKS | 1.12% |
| ARROWHEAD PHARMACEUTICALS | ARWR | 1.11% |
| AMICUS THERAPEUTICS INC | FOLD | 1.03% |
| CIDARA THERAPEUTICS INC | CDTX | 1.02% |
| PTC THERAPEUTICS | PTCT | 1.02% |
| VAXCYTE INC | PCVX | 1.01% |
| AXSOME THERAPEUT | AXSM | 0.94% |
| MADRIGAL PHARMAC | MDGL | 0.89% |
| PROTAGONIST THER | PTGX | 0.89% |
| TG THERAPEUTICS | TGTX | 0.83% |
| ADMA BIOLOGICS INC | ADMA | 0.79% |
| RHYTHM PHARMACEU | RYTM | 0.78% |
| VERACYTE INC | VCYT | 0.78% |
| TRAVERE THERAPEUTICS INC | TVTX | 0.78% |
| ARCUTIS BIOTHERAPEUTICS I | ARQT | 0.76% |
| LEGEND BIOTECH CORP-ADR | LEGN | 0.75% |
| SCHOLAR ROCK HOLDING CORP | SRRK | 0.74% |
| ACADIA PHARMACEUTICALS IN | ACAD | 0.74% |
| ASCENDIS PHA-ADR | ASND | 0.72% |
| VIKING THERAPEUTICS INC | VKTX | 0.71% |
| APELLIS PHARMACE | APLS | 0.67% |
| CELCUITY INC | CELC | 0.65% |
| BEAM THERAPEUTICS INC | BEAM | 0.63% |
| TWIST BIOSCIENCE CORP | TWST | 0.61% |
| RECURSION PHARMACEUTICALS | RXRX | 0.61% |
| SAREPTA THERAPEU | SRPT | 0.60% |
| SOLENO THERAPEUTICS INC | SLNO | 0.60% |
| MIRUM PHARMACEUTICALS INC | MIRM | 0.60% |
| KYMERA THERAPEUTICS INC | KYMR | 0.59% |
| LIQUIDIA CORP | LQDA | 0.59% |
| NUVALENT INC-A | NUVL | 0.57% |
| SUMMIT THERAPEUTICS INC | SMMT | 0.54% |
| KRYSTAL BIOTECH INC | KRYS | 0.54% |
| ULTRAGENYX PHARM | RARE | 0.48% |
| ARCELLX INC | ACLX | 0.43% |
| INTELLIA THERAPE | NTLA | 0.42% |
| GRAIL INC | GRAL | 0.40% |
| Other (Cash, derivatives and other liabilities) | 0.49% | |
| Total: | ||
Read a prospectus and summary prospectus (if available) carefully before investing. It contains the investment objective, risks charges, expenses and the other information, which should be considered carefully before investing. To obtain a prospectus and summary prospectus (if available) click here or call 800.820.0888.
Investing involves risk, including the possible loss of principal.
Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Wealth Solutions, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Private Investments, LLC.
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