| Security Name | Ticker | % of Net Assets |
|---|---|---|
| ABBVIE INC | ABBV | 7.39% |
| AMGEN INC. | AMGN | 5.47% |
| GILEAD SCIENCES, INC. | GILD | 4.72% |
| VERTEX PHARMACEUTICALS | VRTX | 4.00% |
| REGENERON PHARMACEUTICALS | REGN | 3.75% |
| INSMED INC | INSM | 3.00% |
| ALNYLAM PHARMACEUTICALS | ALNY | 2.85% |
| CORTEVA INC | CTVA | 2.38% |
| NATERA INC | NTRA | 2.38% |
| EXACT SCIENCES | EXAS | 2.15% |
| ASTRAZENECA PLC ADR | AZN | 2.07% |
| BIOGEN IDEC, INC. | BIIB | 2.04% |
| ILLUMINA INC | ILMN | 1.83% |
| GUARDANT HEALTH INC | GH | 1.81% |
| BEONE MEDICINES LTD-ADR | BGNE | 1.73% |
| ROYALTY PHARMA PLC- CL A | RPRX | 1.73% |
| INCYTE CORP | INCY | 1.66% |
| REVOLUTION MEDICINES INC | RVMD | 1.62% |
| JAZZ PHARMACEUTICALS PLC | JAZZ | 1.57% |
| AVIDITY BIOSCIENCES INC | RNA | 1.55% |
| BRIDGEBIO PHARMA INC | BBIO | 1.53% |
| IONIS PHARMACEUTICALS, IN | IONS | 1.51% |
| NEUROCRINE BIOSCIENCES IN | NBIX | 1.47% |
| ARROWHEAD PHARMACEUTICALS | ARWR | 1.38% |
| ARGENX SE - ADR | ARGX | 1.37% |
| VIATRIS INC | VTRS | 1.36% |
| UNITED THERAPEUTICS CORP | UTHR | 1.35% |
| EXELIXIS, INC. | EXEL | 1.30% |
| ROIVANT SCIENCES LTD | ROIV | 1.27% |
| BIOMARIN PHARMACEUTICAL | BMRN | 1.19% |
| CYTOKINETICS INC | CYTK | 1.15% |
| VAXCYTE INC | PCVX | 1.05% |
| PTC THERAPEUTICS | PTCT | 1.04% |
| MODERNA INC | MRNA | 1.03% |
| PROTAGONIST THER | PTGX | 1.01% |
| AXSOME THERAPEUT | AXSM | 1.01% |
| ALKERMES PLC | ALKS | 1.00% |
| HALOZYME THERAPEUTICS INC | HALO | 0.97% |
| NUVALENT INC-A | NUVL | 0.93% |
| BIONTECH SE-ADR | BNTX | 0.91% |
| CRINETICS PHARMACEUTICALS | CRNX | 0.90% |
| CRISPR THERAPEUTICS AG | CRSP | 0.89% |
| ADMA BIOLOGICS INC | ADMA | 0.86% |
| VIKING THERAPEUTICS INC | VKTX | 0.85% |
| VERACYTE INC | VCYT | 0.84% |
| AKERO THERAPEUTICS INC | AKRO | 0.83% |
| TG THERAPEUTICS | TGTX | 0.78% |
| DYNE THERAPEUTICS INC | DYN | 0.76% |
| MEDPACE HOLDINGS | MEDP | 0.75% |
| IDEAYA BIOSCIENCES INC | IDYA | 0.74% |
| LEGEND BIOTECH CORP-ADR | LEGN | 0.74% |
| AMICUS THERAPEUTICS INC | FOLD | 0.71% |
| ULTRAGENYX PHARM | RARE | 0.67% |
| ACADIA PHARMACEUTICALS IN | ACAD | 0.66% |
| MADRIGAL PHARMAC | MDGL | 0.63% |
| DENALI THERAPEUT | DNLI | 0.60% |
| BEAM THERAPEUTICS INC | BEAM | 0.56% |
| IMMUNOVANT INC | IMVT | 0.55% |
| APELLIS PHARMACE | APLS | 0.53% |
| SAREPTA THERAPEU | SRPT | 0.52% |
| TWIST BIOSCIENCE CORP | TWST | 0.52% |
| SUMMIT THERAPEUTICS INC | SMMT | 0.50% |
| CELLDEX THERAPEUTICS INC | CLDX | 0.49% |
| ASCENDIS PHA-ADR | ASND | 0.49% |
| ARCELLX INC | ACLX | 0.48% |
| KRYSTAL BIOTECH INC | KRYS | 0.47% |
| RECURSION PHARMACEUTICALS | RXRX | 0.46% |
| DYNAVAX TECHNOLOGY | DVAX | 0.44% |
| AGIOS PHARMACEUT | AGIO | 0.37% |
| NOVAVAX INC | NVAX | 0.34% |
| SOLENO THERAPEUTICS INC | SLNO | 0.33% |
| INTELLIA THERAPE | NTLA | 0.30% |
| IOVANCE BIOTHERAPEUTICS | IOVA | 0.18% |
| Other (Cash, derivatives and other liabilities) | 0.73% | |
| Total: | ||
Read a prospectus and summary prospectus (if available) carefully before investing. It contains the investment objective, risks charges, expenses and the other information, which should be considered carefully before investing. To obtain a prospectus and summary prospectus (if available) click here or call 800.820.0888.
Investing involves risk, including the possible loss of principal.
Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Wealth Solutions, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Private Investments, LLC.
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