| Security Name | Ticker | % of Net Assets |
|---|---|---|
| ABBVIE INC | ABBV | 7.29% |
| GILEAD SCIENCES, INC. | GILD | 5.15% |
| AMGEN INC. | AMGN | 5.14% |
| VERTEX PHARMACEUTICALS | VRTX | 4.53% |
| REGENERON PHARMACEUTICALS | REGN | 3.48% |
| ALNYLAM PHARMACEUTICALS | ALNY | 2.45% |
| BEONE MEDICINES LTD-ADR | BGNE | 2.29% |
| NATERA INC | NTRA | 2.27% |
| ASTRAZENECA PLC ADR | AZN | 2.23% |
| BIOGEN IDEC, INC. | BIIB | 2.12% |
| INSMED INC | INSM | 2.08% |
| MODERNA INC | MRNA | 1.96% |
| ROYALTY PHARMA PLC- CL A | RPRX | 1.96% |
| ILLUMINA INC | ILMN | 1.94% |
| REVOLUTION MEDICINES INC | RVMD | 1.88% |
| EXACT SCIENCES | EXAS | 1.77% |
| UNITED THERAPEUTICS CORP | UTHR | 1.77% |
| VIATRIS INC | VTRS | 1.68% |
| INCYTE CORP | INCY | 1.67% |
| GUARDANT HEALTH INC | GH | 1.61% |
| BRIDGEBIO PHARMA INC | BBIO | 1.49% |
| IONIS PHARMACEUTICALS, IN | IONS | 1.48% |
| ARGENX SE - ADR | ARGX | 1.41% |
| NEUROCRINE BIOSCIENCES IN | NBIX | 1.40% |
| BIOMARIN PHARMACEUTICAL | BMRN | 1.37% |
| ALKERMES PLC | ALKS | 1.34% |
| EXELIXIS, INC. | EXEL | 1.32% |
| AVIDITY BIOSCIENCES INC | RNA | 1.32% |
| BIONTECH SE-ADR | BNTX | 1.31% |
| JAZZ PHARMACEUTICALS PLC | JAZZ | 1.28% |
| HALOZYME THERAPEUTICS INC | HALO | 1.26% |
| MEDPACE HOLDINGS | MEDP | 1.21% |
| ROIVANT SCIENCES LTD | ROIV | 1.20% |
| ARROWHEAD PHARMACEUTICALS | ARWR | 1.19% |
| VAXCYTE INC | PCVX | 1.15% |
| CYTOKINETICS INC | CYTK | 1.15% |
| CRISPR THERAPEUTICS AG | CRSP | 1.07% |
| AMICUS THERAPEUTICS INC | FOLD | 1.02% |
| AXSOME THERAPEUT | AXSM | 0.99% |
| PTC THERAPEUTICS | PTCT | 0.98% |
| PROTAGONIST THER | PTGX | 0.85% |
| TG THERAPEUTICS | TGTX | 0.80% |
| MIRUM PHARMACEUTICALS INC | MIRM | 0.80% |
| RHYTHM PHARMACEU | RYTM | 0.77% |
| LIQUIDIA CORP | LQDA | 0.76% |
| SCHOLAR ROCK HOLDING CORP | SRRK | 0.76% |
| ASCENDIS PHA-ADR | ASND | 0.75% |
| ADMA BIOLOGICS INC | ADMA | 0.74% |
| MADRIGAL PHARMAC | MDGL | 0.73% |
| TWIST BIOSCIENCE CORP | TWST | 0.72% |
| ACADIA PHARMACEUTICALS IN | ACAD | 0.70% |
| VERACYTE INC | VCYT | 0.67% |
| CELCUITY INC | CELC | 0.67% |
| BEAM THERAPEUTICS INC | BEAM | 0.64% |
| LEGEND BIOTECH CORP-ADR | LEGN | 0.63% |
| VIKING THERAPEUTICS INC | VKTX | 0.63% |
| ARCUTIS BIOTHERAPEUTICS I | ARQT | 0.63% |
| TRAVERE THERAPEUTICS INC | TVTX | 0.62% |
| KRYSTAL BIOTECH INC | KRYS | 0.61% |
| APELLIS PHARMACE | APLS | 0.60% |
| NUVALENT INC-A | NUVL | 0.59% |
| KYMERA THERAPEUTICS INC | KYMR | 0.59% |
| INTELLIA THERAPE | NTLA | 0.58% |
| RECURSION PHARMACEUTICALS | RXRX | 0.57% |
| SAREPTA THERAPEU | SRPT | 0.57% |
| SOLENO THERAPEUTICS INC | SLNO | 0.50% |
| ULTRAGENYX PHARM | RARE | 0.49% |
| ARCELLX INC | ACLX | 0.46% |
| SUMMIT THERAPEUTICS INC | SMMT | 0.44% |
| GRAIL INC | GRAL | 0.40% |
| Other (Cash, derivatives and other liabilities) | 0.53% | |
| Total: | ||
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Investing involves risk, including the possible loss of principal.
Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Wealth Solutions, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Private Investments, LLC.
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