| Security Name | Ticker | % of Net Assets |
|---|---|---|
| ABBVIE INC | ABBV | 7.58% |
| AMGEN INC. | AMGN | 5.52% |
| GILEAD SCIENCES, INC. | GILD | 4.95% |
| VERTEX PHARMACEUTICALS | VRTX | 4.17% |
| REGENERON PHARMACEUTICALS | REGN | 3.42% |
| ALNYLAM PHARMACEUTICALS | ALNY | 2.90% |
| INSMED INC | INSM | 2.83% |
| CORTEVA INC | CTVA | 2.43% |
| NATERA INC | NTRA | 2.16% |
| ASTRAZENECA PLC ADR | AZN | 1.97% |
| BIOGEN IDEC, INC. | BIIB | 1.88% |
| ROYALTY PHARMA PLC- CL A | RPRX | 1.86% |
| ILLUMINA INC | ILMN | 1.86% |
| INCYTE CORP | INCY | 1.83% |
| BEONE MEDICINES LTD-ADR | BGNE | 1.76% |
| GUARDANT HEALTH INC | GH | 1.74% |
| AVIDITY BIOSCIENCES INC | RNA | 1.61% |
| NEUROCRINE BIOSCIENCES IN | NBIX | 1.59% |
| EXACT SCIENCES | EXAS | 1.58% |
| IONIS PHARMACEUTICALS, IN | IONS | 1.46% |
| VIATRIS INC | VTRS | 1.46% |
| BRIDGEBIO PHARMA INC | BBIO | 1.42% |
| ARGENX SE - ADR | ARGX | 1.36% |
| ROIVANT SCIENCES LTD | ROIV | 1.35% |
| REVOLUTION MEDICINES INC | RVMD | 1.35% |
| UNITED THERAPEUTICS CORP | UTHR | 1.34% |
| JAZZ PHARMACEUTICALS PLC | JAZZ | 1.33% |
| EXELIXIS, INC. | EXEL | 1.29% |
| BIOMARIN PHARMACEUTICAL | BMRN | 1.21% |
| ALKERMES PLC | ALKS | 1.14% |
| CYTOKINETICS INC | CYTK | 1.10% |
| MODERNA INC | MRNA | 1.07% |
| ARROWHEAD PHARMACEUTICALS | ARWR | 1.06% |
| HALOZYME THERAPEUTICS INC | HALO | 1.04% |
| CRISPR THERAPEUTICS AG | CRSP | 1.03% |
| BIONTECH SE-ADR | BNTX | 1.03% |
| PTC THERAPEUTICS | PTCT | 1.00% |
| VAXCYTE INC | PCVX | 0.99% |
| PROTAGONIST THER | PTGX | 0.98% |
| AXSOME THERAPEUT | AXSM | 0.98% |
| VIKING THERAPEUTICS INC | VKTX | 0.95% |
| LEGEND BIOTECH CORP-ADR | LEGN | 0.93% |
| CRINETICS PHARMACEUTICALS | CRNX | 0.90% |
| TG THERAPEUTICS | TGTX | 0.90% |
| VERACYTE INC | VCYT | 0.89% |
| AKERO THERAPEUTICS INC | AKRO | 0.88% |
| NUVALENT INC-A | NUVL | 0.85% |
| DYNE THERAPEUTICS INC | DYN | 0.82% |
| MEDPACE HOLDINGS | MEDP | 0.82% |
| ADMA BIOLOGICS INC | ADMA | 0.73% |
| AMICUS THERAPEUTICS INC | FOLD | 0.71% |
| ULTRAGENYX PHARM | RARE | 0.69% |
| IDEAYA BIOSCIENCES INC | IDYA | 0.69% |
| ACADIA PHARMACEUTICALS IN | ACAD | 0.64% |
| ARCELLX INC | ACLX | 0.63% |
| IMMUNOVANT INC | IMVT | 0.61% |
| TWIST BIOSCIENCE CORP | TWST | 0.59% |
| AGIOS PHARMACEUT | AGIO | 0.57% |
| BEAM THERAPEUTICS INC | BEAM | 0.57% |
| SUMMIT THERAPEUTICS INC | SMMT | 0.56% |
| MADRIGAL PHARMAC | MDGL | 0.55% |
| RECURSION PHARMACEUTICALS | RXRX | 0.55% |
| APELLIS PHARMACE | APLS | 0.53% |
| SAREPTA THERAPEU | SRPT | 0.53% |
| DENALI THERAPEUT | DNLI | 0.52% |
| INTELLIA THERAPE | NTLA | 0.52% |
| ASCENDIS PHA-ADR | ASND | 0.49% |
| CELLDEX THERAPEUTICS INC | CLDX | 0.48% |
| KRYSTAL BIOTECH INC | KRYS | 0.47% |
| DYNAVAX TECHNOLOGY | DVAX | 0.45% |
| NOVAVAX INC | NVAX | 0.41% |
| SOLENO THERAPEUTICS INC | SLNO | 0.34% |
| IOVANCE BIOTHERAPEUTICS | IOVA | 0.16% |
| Other (Cash, derivatives and other liabilities) | 0.44% | |
| Total: | ||
Read a prospectus and summary prospectus (if available) carefully before investing. It contains the investment objective, risks charges, expenses and the other information, which should be considered carefully before investing. To obtain a prospectus and summary prospectus (if available) click here or call 800.820.0888.
Investing involves risk, including the possible loss of principal.
Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Wealth Solutions, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Private Investments, LLC.
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