| Security Name | Ticker | % of Net Assets |
|---|---|---|
| ABBVIE INC | ABBV | 7.00% |
| AMGEN INC. | AMGN | 5.34% |
| GILEAD SCIENCES, INC. | GILD | 4.78% |
| VERTEX PHARMACEUTICALS | VRTX | 4.27% |
| REGENERON PHARMACEUTICALS | REGN | 3.67% |
| BEONE MEDICINES LTD-ADR | BGNE | 2.47% |
| ASTRAZENECA PLC | AZN | 2.44% |
| ALNYLAM PHARMACEUTICALS | ALNY | 2.37% |
| BIOGEN IDEC, INC. | BIIB | 2.30% |
| MODERNA INC | MRNA | 2.22% |
| ROYALTY PHARMA PLC- CL A | RPRX | 2.12% |
| INSMED INC | INSM | 2.09% |
| NATERA INC | NTRA | 2.04% |
| VIATRIS INC | VTRS | 2.03% |
| REVOLUTION MEDICINES INC | RVMD | 2.00% |
| UNITED THERAPEUTICS CORP | UTHR | 1.78% |
| EXACT SCIENCES | EXAS | 1.78% |
| INCYTE CORP | INCY | 1.67% |
| ILLUMINA INC | ILMN | 1.60% |
| ROIVANT SCIENCES LTD | ROIV | 1.53% |
| BIOMARIN PHARMACEUTICAL | BMRN | 1.51% |
| IONIS PHARMACEUTICALS, IN | IONS | 1.51% |
| EXELIXIS, INC. | EXEL | 1.39% |
| ARGENX SE - ADR | ARGX | 1.38% |
| JAZZ PHARMACEUTICALS PLC | JAZZ | 1.34% |
| GUARDANT HEALTH INC | GH | 1.33% |
| AVIDITY BIOSCIENCES INC | RNA | 1.31% |
| NEUROCRINE BIOSCIENCES IN | NBIX | 1.31% |
| BRIDGEBIO PHARMA INC | BBIO | 1.30% |
| VAXCYTE INC | PCVX | 1.29% |
| BIONTECH SE-ADR | BNTX | 1.26% |
| ALKERMES PLC | ALKS | 1.26% |
| HALOZYME THERAPEUTICS INC | HALO | 1.24% |
| CYTOKINETICS INC | CYTK | 1.23% |
| CRISPR THERAPEUTICS AG | CRSP | 1.15% |
| ARROWHEAD PHARMACEUTICALS | ARWR | 1.07% |
| AMICUS THERAPEUTICS INC | FOLD | 1.01% |
| AXSOME THERAPEUT | AXSM | 0.94% |
| MEDPACE HOLDINGS | MEDP | 0.92% |
| PTC THERAPEUTICS | PTCT | 0.91% |
| PROTAGONIST THER | PTGX | 0.89% |
| TWIST BIOSCIENCE CORP | TWST | 0.83% |
| TG THERAPEUTICS | TGTX | 0.83% |
| MIRUM PHARMACEUTICALS INC | MIRM | 0.81% |
| SCHOLAR ROCK HOLDING CORP | SRRK | 0.80% |
| ASCENDIS PHA-ADR | ASND | 0.78% |
| ARCELLX INC | ACLX | 0.76% |
| VIKING THERAPEUTICS INC | VKTX | 0.75% |
| RHYTHM PHARMACEU | RYTM | 0.72% |
| LEGEND BIOTECH CORP-ADR | LEGN | 0.71% |
| KYMERA THERAPEUTICS INC | KYMR | 0.71% |
| ADMA BIOLOGICS INC | ADMA | 0.69% |
| ACADIA PHARMACEUTICALS IN | ACAD | 0.68% |
| BEAM THERAPEUTICS INC | BEAM | 0.65% |
| MADRIGAL PHARMAC | MDGL | 0.65% |
| ARCUTIS BIOTHERAPEUTICS I | ARQT | 0.65% |
| CELCUITY INC | CELC | 0.64% |
| VERACYTE INC | VCYT | 0.62% |
| TRAVERE THERAPEUTICS INC | TVTX | 0.61% |
| APELLIS PHARMACE | APLS | 0.59% |
| KRYSTAL BIOTECH INC | KRYS | 0.59% |
| NUVALENT INC-A | NUVL | 0.58% |
| LIQUIDIA CORP | LQDA | 0.58% |
| INTELLIA THERAPE | NTLA | 0.58% |
| SOLENO THERAPEUTICS INC | SLNO | 0.51% |
| SAREPTA THERAPEU | SRPT | 0.50% |
| SUMMIT THERAPEUTICS INC | SMMT | 0.49% |
| RECURSION PHARMACEUTICALS | RXRX | 0.46% |
| ULTRAGENYX PHARM | RARE | 0.45% |
| GRAIL INC | GRAL | 0.17% |
| Other (Cash, derivatives and other liabilities) | 0.56% | |
| Total: | ||
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Investing involves risk, including the possible loss of principal.
Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Wealth Solutions, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Private Investments, LLC.
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