| Security Name | Ticker | % of Net Assets |
|---|---|---|
| ABBVIE INC | ABBV | 7.25% |
| AMGEN INC. | AMGN | 4.90% |
| GILEAD SCIENCES, INC. | GILD | 4.44% |
| VERTEX PHARMACEUTICALS | VRTX | 4.41% |
| REGENERON PHARMACEUTICALS | REGN | 3.58% |
| ALNYLAM PHARMACEUTICALS | ALNY | 2.69% |
| BEONE MEDICINES LTD-ADR | BGNE | 2.37% |
| NATERA INC | NTRA | 2.35% |
| REVOLUTION MEDICINES INC | RVMD | 2.34% |
| ASTRAZENECA PLC ADR | AZN | 2.28% |
| INSMED INC | INSM | 2.18% |
| BIOGEN IDEC, INC. | BIIB | 2.11% |
| ILLUMINA INC | ILMN | 1.98% |
| ROYALTY PHARMA PLC- CL A | RPRX | 1.90% |
| UNITED THERAPEUTICS CORP | UTHR | 1.81% |
| EXACT SCIENCES | EXAS | 1.78% |
| MODERNA INC | MRNA | 1.77% |
| INCYTE CORP | INCY | 1.73% |
| VIATRIS INC | VTRS | 1.72% |
| BRIDGEBIO PHARMA INC | BBIO | 1.53% |
| GUARDANT HEALTH INC | GH | 1.52% |
| IONIS PHARMACEUTICALS, IN | IONS | 1.43% |
| EXELIXIS, INC. | EXEL | 1.41% |
| ARGENX SE - ADR | ARGX | 1.37% |
| NEUROCRINE BIOSCIENCES IN | NBIX | 1.37% |
| BIOMARIN PHARMACEUTICAL | BMRN | 1.34% |
| AVIDITY BIOSCIENCES INC | RNA | 1.32% |
| ROIVANT SCIENCES LTD | ROIV | 1.31% |
| JAZZ PHARMACEUTICALS PLC | JAZZ | 1.28% |
| MEDPACE HOLDINGS | MEDP | 1.27% |
| HALOZYME THERAPEUTICS INC | HALO | 1.27% |
| BIONTECH SE-ADR | BNTX | 1.24% |
| CRISPR THERAPEUTICS AG | CRSP | 1.21% |
| ALKERMES PLC | ALKS | 1.16% |
| CYTOKINETICS INC | CYTK | 1.15% |
| ARROWHEAD PHARMACEUTICALS | ARWR | 1.13% |
| AMICUS THERAPEUTICS INC | FOLD | 1.02% |
| VAXCYTE INC | PCVX | 1.00% |
| PTC THERAPEUTICS | PTCT | 0.99% |
| AXSOME THERAPEUT | AXSM | 0.95% |
| PROTAGONIST THER | PTGX | 0.85% |
| LEGEND BIOTECH CORP-ADR | LEGN | 0.82% |
| RHYTHM PHARMACEU | RYTM | 0.82% |
| BEAM THERAPEUTICS INC | BEAM | 0.80% |
| ADMA BIOLOGICS INC | ADMA | 0.76% |
| TG THERAPEUTICS | TGTX | 0.76% |
| VERACYTE INC | VCYT | 0.76% |
| SCHOLAR ROCK HOLDING CORP | SRRK | 0.75% |
| ACADIA PHARMACEUTICALS IN | ACAD | 0.74% |
| MADRIGAL PHARMAC | MDGL | 0.74% |
| ASCENDIS PHA-ADR | ASND | 0.72% |
| TWIST BIOSCIENCE CORP | TWST | 0.71% |
| MIRUM PHARMACEUTICALS INC | MIRM | 0.70% |
| LIQUIDIA CORP | LQDA | 0.69% |
| VIKING THERAPEUTICS INC | VKTX | 0.67% |
| ARCUTIS BIOTHERAPEUTICS I | ARQT | 0.65% |
| RECURSION PHARMACEUTICALS | RXRX | 0.64% |
| CELCUITY INC | CELC | 0.64% |
| KRYSTAL BIOTECH INC | KRYS | 0.64% |
| SAREPTA THERAPEU | SRPT | 0.60% |
| KYMERA THERAPEUTICS INC | KYMR | 0.60% |
| TRAVERE THERAPEUTICS INC | TVTX | 0.59% |
| NUVALENT INC-A | NUVL | 0.58% |
| APELLIS PHARMACE | APLS | 0.57% |
| SOLENO THERAPEUTICS INC | SLNO | 0.54% |
| INTELLIA THERAPE | NTLA | 0.52% |
| SUMMIT THERAPEUTICS INC | SMMT | 0.52% |
| ULTRAGENYX PHARM | RARE | 0.49% |
| ARCELLX INC | ACLX | 0.45% |
| GRAIL INC | GRAL | 0.42% |
| Other (Cash, derivatives and other liabilities) | 0.40% | |
| Total: | ||
Read a prospectus and summary prospectus (if available) carefully before investing. It contains the investment objective, risks charges, expenses and the other information, which should be considered carefully before investing. To obtain a prospectus and summary prospectus (if available) click here or call 800.820.0888.
Investing involves risk, including the possible loss of principal.
Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Wealth Solutions, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Private Investments, LLC.
© 2026 Guggenheim Investments. All Rights Reserved.
Research our firm with FINRA Broker Check.
• Not FDIC Insured • No Bank Guarantee • May Lose Value
This website is directed to and intended for use by citizens or residents of the United States of America only. The material provided on this website is not intended as a recommendation or as investment advice of any kind, including in connection with rollovers, transfers, and distributions. Such material is not provided in a fiduciary capacity, may not be relied upon for or in connection with the making of investment decisions, and does not constitute a solicitation of an offer to buy or sell securities. All content has been provided for informational or educational purposes only and is not intended to be and should not be construed as legal or tax advice and/or a legal opinion. Always consult a financial, tax and/or legal professional regarding your specific situation. Investing involves risk, including the possible loss of principal.