| Security Name | Ticker | % of Net Assets |
|---|---|---|
| ABBVIE INC | ABBV | 7.07% |
| AMGEN INC. | AMGN | 5.03% |
| GILEAD SCIENCES, INC. | GILD | 4.55% |
| VERTEX PHARMACEUTICALS | VRTX | 4.31% |
| REGENERON PHARMACEUTICALS | REGN | 3.48% |
| ALNYLAM PHARMACEUTICALS | ALNY | 2.60% |
| NATERA INC | NTRA | 2.33% |
| REVOLUTION MEDICINES INC | RVMD | 2.28% |
| BEONE MEDICINES LTD-ADR | BGNE | 2.27% |
| INSMED INC | INSM | 2.19% |
| ASTRAZENECA PLC ADR | AZN | 2.18% |
| ILLUMINA INC | ILMN | 1.99% |
| BIOGEN IDEC, INC. | BIIB | 1.97% |
| MODERNA INC | MRNA | 1.94% |
| ROYALTY PHARMA PLC- CL A | RPRX | 1.85% |
| EXACT SCIENCES | EXAS | 1.79% |
| UNITED THERAPEUTICS CORP | UTHR | 1.78% |
| INCYTE CORP | INCY | 1.73% |
| GUARDANT HEALTH INC | GH | 1.64% |
| VIATRIS INC | VTRS | 1.64% |
| BRIDGEBIO PHARMA INC | BBIO | 1.51% |
| EXELIXIS, INC. | EXEL | 1.41% |
| IONIS PHARMACEUTICALS, IN | IONS | 1.40% |
| NEUROCRINE BIOSCIENCES IN | NBIX | 1.40% |
| BIOMARIN PHARMACEUTICAL | BMRN | 1.38% |
| ARGENX SE - ADR | ARGX | 1.37% |
| AVIDITY BIOSCIENCES INC | RNA | 1.33% |
| JAZZ PHARMACEUTICALS PLC | JAZZ | 1.33% |
| ROIVANT SCIENCES LTD | ROIV | 1.29% |
| ALKERMES PLC | ALKS | 1.27% |
| MEDPACE HOLDINGS | MEDP | 1.26% |
| HALOZYME THERAPEUTICS INC | HALO | 1.25% |
| BIONTECH SE-ADR | BNTX | 1.23% |
| CYTOKINETICS INC | CYTK | 1.17% |
| CRISPR THERAPEUTICS AG | CRSP | 1.14% |
| ARROWHEAD PHARMACEUTICALS | ARWR | 1.13% |
| VAXCYTE INC | PCVX | 1.03% |
| AMICUS THERAPEUTICS INC | FOLD | 1.03% |
| AXSOME THERAPEUT | AXSM | 1.01% |
| PTC THERAPEUTICS | PTCT | 0.96% |
| PROTAGONIST THER | PTGX | 0.87% |
| LEGEND BIOTECH CORP-ADR | LEGN | 0.86% |
| TG THERAPEUTICS | TGTX | 0.85% |
| RHYTHM PHARMACEU | RYTM | 0.78% |
| SCHOLAR ROCK HOLDING CORP | SRRK | 0.77% |
| ADMA BIOLOGICS INC | ADMA | 0.76% |
| MADRIGAL PHARMAC | MDGL | 0.76% |
| VERACYTE INC | VCYT | 0.74% |
| ACADIA PHARMACEUTICALS IN | ACAD | 0.74% |
| VIKING THERAPEUTICS INC | VKTX | 0.74% |
| TWIST BIOSCIENCE CORP | TWST | 0.74% |
| ASCENDIS PHA-ADR | ASND | 0.73% |
| BEAM THERAPEUTICS INC | BEAM | 0.72% |
| MIRUM PHARMACEUTICALS INC | MIRM | 0.72% |
| LIQUIDIA CORP | LQDA | 0.71% |
| CELCUITY INC | CELC | 0.65% |
| ARCUTIS BIOTHERAPEUTICS I | ARQT | 0.65% |
| NUVALENT INC-A | NUVL | 0.61% |
| RECURSION PHARMACEUTICALS | RXRX | 0.60% |
| KRYSTAL BIOTECH INC | KRYS | 0.60% |
| SAREPTA THERAPEU | SRPT | 0.59% |
| SOLENO THERAPEUTICS INC | SLNO | 0.57% |
| INTELLIA THERAPE | NTLA | 0.57% |
| TRAVERE THERAPEUTICS INC | TVTX | 0.57% |
| KYMERA THERAPEUTICS INC | KYMR | 0.56% |
| APELLIS PHARMACE | APLS | 0.55% |
| SUMMIT THERAPEUTICS INC | SMMT | 0.50% |
| ARCELLX INC | ACLX | 0.49% |
| ULTRAGENYX PHARM | RARE | 0.46% |
| GRAIL INC | GRAL | 0.42% |
| Other (Cash, derivatives and other liabilities) | 0.60% | |
| Total: | ||
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Investing involves risk, including the possible loss of principal.
Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Wealth Solutions, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Private Investments, LLC.
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