| Security Name | Ticker | % of Net Assets |
|---|---|---|
| ABBVIE INC | ABBV | 7.32% |
| AMGEN INC. | AMGN | 4.89% |
| GILEAD SCIENCES, INC. | GILD | 4.42% |
| VERTEX PHARMACEUTICALS | VRTX | 4.36% |
| REGENERON PHARMACEUTICALS | REGN | 3.59% |
| ALNYLAM PHARMACEUTICALS | ALNY | 2.90% |
| INSMED INC | INSM | 2.28% |
| NATERA INC | NTRA | 2.27% |
| ASTRAZENECA PLC ADR | AZN | 2.16% |
| BEONE MEDICINES LTD-ADR | BGNE | 2.07% |
| BIOGEN IDEC, INC. | BIIB | 2.02% |
| UNITED THERAPEUTICS CORP | UTHR | 1.90% |
| ILLUMINA INC | ILMN | 1.81% |
| ROYALTY PHARMA PLC- CL A | RPRX | 1.79% |
| EXACT SCIENCES | EXAS | 1.73% |
| INCYTE CORP | INCY | 1.65% |
| REVOLUTION MEDICINES INC | RVMD | 1.54% |
| MODERNA INC | MRNA | 1.53% |
| VIATRIS INC | VTRS | 1.51% |
| NEUROCRINE BIOSCIENCES IN | NBIX | 1.49% |
| BRIDGEBIO PHARMA INC | BBIO | 1.46% |
| EXELIXIS, INC. | EXEL | 1.45% |
| IONIS PHARMACEUTICALS, IN | IONS | 1.43% |
| GUARDANT HEALTH INC | GH | 1.41% |
| BIOMARIN PHARMACEUTICAL | BMRN | 1.41% |
| ARGENX SE - ADR | ARGX | 1.41% |
| JAZZ PHARMACEUTICALS PLC | JAZZ | 1.30% |
| AVIDITY BIOSCIENCES INC | RNA | 1.29% |
| ROIVANT SCIENCES LTD | ROIV | 1.24% |
| CRISPR THERAPEUTICS AG | CRSP | 1.22% |
| CYTOKINETICS INC | CYTK | 1.18% |
| HALOZYME THERAPEUTICS INC | HALO | 1.18% |
| MEDPACE HOLDINGS | MEDP | 1.17% |
| ARROWHEAD PHARMACEUTICALS | ARWR | 1.16% |
| ALKERMES PLC | ALKS | 1.11% |
| BIONTECH SE-ADR | BNTX | 1.05% |
| VAXCYTE INC | PCVX | 1.02% |
| PTC THERAPEUTICS | PTCT | 1.01% |
| AMICUS THERAPEUTICS INC | FOLD | 0.99% |
| CIDARA THERAPEUTICS INC | CDTX | 0.98% |
| MERUS NV | MRUS | 0.98% |
| PROTAGONIST THER | PTGX | 0.89% |
| MADRIGAL PHARMAC | MDGL | 0.88% |
| ADMA BIOLOGICS INC | ADMA | 0.84% |
| RHYTHM PHARMACEU | RYTM | 0.84% |
| TG THERAPEUTICS | TGTX | 0.83% |
| AXSOME THERAPEUT | AXSM | 0.82% |
| LEGEND BIOTECH CORP-ADR | LEGN | 0.81% |
| ACADIA PHARMACEUTICALS IN | ACAD | 0.77% |
| VIKING THERAPEUTICS INC | VKTX | 0.76% |
| SCHOLAR ROCK HOLDING CORP | SRRK | 0.76% |
| VERACYTE INC | VCYT | 0.74% |
| ARCUTIS BIOTHERAPEUTICS I | ARQT | 0.73% |
| TRAVERE THERAPEUTICS INC | TVTX | 0.72% |
| ULTRAGENYX PHARM | RARE | 0.69% |
| ASCENDIS PHA-ADR | ASND | 0.68% |
| KYMERA THERAPEUTICS INC | KYMR | 0.67% |
| APELLIS PHARMACE | APLS | 0.66% |
| BEAM THERAPEUTICS INC | BEAM | 0.63% |
| LIQUIDIA CORP | LQDA | 0.63% |
| SOLENO THERAPEUTICS INC | SLNO | 0.63% |
| MIRUM PHARMACEUTICALS INC | MIRM | 0.62% |
| CELCUITY INC | CELC | 0.61% |
| TWIST BIOSCIENCE CORP | TWST | 0.60% |
| NUVALENT INC-A | NUVL | 0.59% |
| RECURSION PHARMACEUTICALS | RXRX | 0.59% |
| SAREPTA THERAPEU | SRPT | 0.58% |
| SUMMIT THERAPEUTICS INC | SMMT | 0.55% |
| KRYSTAL BIOTECH INC | KRYS | 0.53% |
| ARCELLX INC | ACLX | 0.43% |
| INTELLIA THERAPE | NTLA | 0.42% |
| GRAIL INC | GRAL | 0.38% |
| Other (Cash, derivatives and other liabilities) | 0.44% | |
| Total: | ||
Read a prospectus and summary prospectus (if available) carefully before investing. It contains the investment objective, risks charges, expenses and the other information, which should be considered carefully before investing. To obtain a prospectus and summary prospectus (if available) click here or call 800.820.0888.
Investing involves risk, including the possible loss of principal.
Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Wealth Solutions, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Private Investments, LLC.
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