| Security Name | Ticker | % of Net Assets |
|---|---|---|
| ABBVIE INC | ABBV | 7.14% |
| AMGEN INC. | AMGN | 5.00% |
| GILEAD SCIENCES, INC. | GILD | 4.44% |
| VERTEX PHARMACEUTICALS | VRTX | 4.27% |
| REGENERON PHARMACEUTICALS | REGN | 3.51% |
| ALNYLAM PHARMACEUTICALS | ALNY | 2.62% |
| REVOLUTION MEDICINES INC | RVMD | 2.42% |
| NATERA INC | NTRA | 2.38% |
| BEONE MEDICINES LTD-ADR | BGNE | 2.29% |
| ASTRAZENECA PLC ADR | AZN | 2.28% |
| INSMED INC | INSM | 2.12% |
| BIOGEN IDEC, INC. | BIIB | 2.00% |
| ILLUMINA INC | ILMN | 1.96% |
| ROYALTY PHARMA PLC- CL A | RPRX | 1.88% |
| UNITED THERAPEUTICS CORP | UTHR | 1.79% |
| EXACT SCIENCES | EXAS | 1.78% |
| INCYTE CORP | INCY | 1.77% |
| MODERNA INC | MRNA | 1.77% |
| VIATRIS INC | VTRS | 1.66% |
| GUARDANT HEALTH INC | GH | 1.60% |
| BRIDGEBIO PHARMA INC | BBIO | 1.48% |
| EXELIXIS, INC. | EXEL | 1.46% |
| IONIS PHARMACEUTICALS, IN | IONS | 1.40% |
| NEUROCRINE BIOSCIENCES IN | NBIX | 1.38% |
| ARGENX SE - ADR | ARGX | 1.38% |
| JAZZ PHARMACEUTICALS PLC | JAZZ | 1.35% |
| BIOMARIN PHARMACEUTICAL | BMRN | 1.34% |
| AVIDITY BIOSCIENCES INC | RNA | 1.33% |
| ROIVANT SCIENCES LTD | ROIV | 1.31% |
| MEDPACE HOLDINGS | MEDP | 1.29% |
| HALOZYME THERAPEUTICS INC | HALO | 1.28% |
| ALKERMES PLC | ALKS | 1.24% |
| BIONTECH SE-ADR | BNTX | 1.24% |
| CRISPR THERAPEUTICS AG | CRSP | 1.17% |
| CYTOKINETICS INC | CYTK | 1.16% |
| ARROWHEAD PHARMACEUTICALS | ARWR | 1.14% |
| VAXCYTE INC | PCVX | 1.04% |
| AMICUS THERAPEUTICS INC | FOLD | 1.03% |
| PTC THERAPEUTICS | PTCT | 0.99% |
| AXSOME THERAPEUT | AXSM | 0.95% |
| PROTAGONIST THER | PTGX | 0.89% |
| TG THERAPEUTICS | TGTX | 0.84% |
| LEGEND BIOTECH CORP-ADR | LEGN | 0.81% |
| RHYTHM PHARMACEU | RYTM | 0.81% |
| SCHOLAR ROCK HOLDING CORP | SRRK | 0.80% |
| ADMA BIOLOGICS INC | ADMA | 0.76% |
| BEAM THERAPEUTICS INC | BEAM | 0.75% |
| MADRIGAL PHARMAC | MDGL | 0.75% |
| ACADIA PHARMACEUTICALS IN | ACAD | 0.75% |
| VERACYTE INC | VCYT | 0.73% |
| TWIST BIOSCIENCE CORP | TWST | 0.73% |
| ASCENDIS PHA-ADR | ASND | 0.72% |
| MIRUM PHARMACEUTICALS INC | MIRM | 0.72% |
| LIQUIDIA CORP | LQDA | 0.70% |
| VIKING THERAPEUTICS INC | VKTX | 0.70% |
| ARCUTIS BIOTHERAPEUTICS I | ARQT | 0.66% |
| CELCUITY INC | CELC | 0.65% |
| RECURSION PHARMACEUTICALS | RXRX | 0.64% |
| KRYSTAL BIOTECH INC | KRYS | 0.62% |
| NUVALENT INC-A | NUVL | 0.61% |
| SAREPTA THERAPEU | SRPT | 0.60% |
| KYMERA THERAPEUTICS INC | KYMR | 0.58% |
| TRAVERE THERAPEUTICS INC | TVTX | 0.57% |
| APELLIS PHARMACE | APLS | 0.55% |
| SOLENO THERAPEUTICS INC | SLNO | 0.55% |
| SUMMIT THERAPEUTICS INC | SMMT | 0.53% |
| INTELLIA THERAPE | NTLA | 0.53% |
| ULTRAGENYX PHARM | RARE | 0.48% |
| ARCELLX INC | ACLX | 0.47% |
| GRAIL INC | GRAL | 0.40% |
| Other (Cash, derivatives and other liabilities) | 0.46% | |
| Total: | ||
Read a prospectus and summary prospectus (if available) carefully before investing. It contains the investment objective, risks charges, expenses and the other information, which should be considered carefully before investing. To obtain a prospectus and summary prospectus (if available) click here or call 800.820.0888.
Investing involves risk, including the possible loss of principal.
Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Wealth Solutions, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Private Investments, LLC.
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