| Security Name | Ticker | % of Net Assets |
|---|---|---|
| ABBVIE INC | ABBV | 6.87% |
| AMGEN INC. | AMGN | 5.30% |
| GILEAD SCIENCES, INC. | GILD | 4.83% |
| VERTEX PHARMACEUTICALS | VRTX | 4.18% |
| REGENERON PHARMACEUTICALS | REGN | 3.66% |
| ASTRAZENECA PLC | AZN | 2.50% |
| ALNYLAM PHARMACEUTICALS | ALNY | 2.45% |
| BEONE MEDICINES LTD-ADR | BGNE | 2.37% |
| BIOGEN IDEC, INC. | BIIB | 2.25% |
| MODERNA INC | MRNA | 2.21% |
| INSMED INC | INSM | 2.12% |
| NATERA INC | NTRA | 2.12% |
| ROYALTY PHARMA PLC- CL A | RPRX | 2.11% |
| VIATRIS INC | VTRS | 2.04% |
| REVOLUTION MEDICINES INC | RVMD | 1.99% |
| UNITED THERAPEUTICS CORP | UTHR | 1.80% |
| EXACT SCIENCES | EXAS | 1.78% |
| INCYTE CORP | INCY | 1.69% |
| ILLUMINA INC | ILMN | 1.60% |
| BIOMARIN PHARMACEUTICAL | BMRN | 1.53% |
| ROIVANT SCIENCES LTD | ROIV | 1.52% |
| GUARDANT HEALTH INC | GH | 1.50% |
| IONIS PHARMACEUTICALS, IN | IONS | 1.49% |
| ARGENX SE - ADR | ARGX | 1.42% |
| EXELIXIS, INC. | EXEL | 1.40% |
| BRIDGEBIO PHARMA INC | BBIO | 1.36% |
| NEUROCRINE BIOSCIENCES IN | NBIX | 1.33% |
| JAZZ PHARMACEUTICALS PLC | JAZZ | 1.32% |
| AVIDITY BIOSCIENCES INC | RNA | 1.32% |
| BIONTECH SE-ADR | BNTX | 1.27% |
| HALOZYME THERAPEUTICS INC | HALO | 1.26% |
| ALKERMES PLC | ALKS | 1.26% |
| VAXCYTE INC | PCVX | 1.23% |
| CYTOKINETICS INC | CYTK | 1.23% |
| CRISPR THERAPEUTICS AG | CRSP | 1.17% |
| ARROWHEAD PHARMACEUTICALS | ARWR | 1.09% |
| AMICUS THERAPEUTICS INC | FOLD | 1.02% |
| AXSOME THERAPEUT | AXSM | 1.00% |
| MEDPACE HOLDINGS | MEDP | 0.92% |
| TWIST BIOSCIENCE CORP | TWST | 0.91% |
| PTC THERAPEUTICS | PTCT | 0.91% |
| PROTAGONIST THER | PTGX | 0.86% |
| MIRUM PHARMACEUTICALS INC | MIRM | 0.81% |
| SCHOLAR ROCK HOLDING CORP | SRRK | 0.81% |
| TG THERAPEUTICS | TGTX | 0.80% |
| RHYTHM PHARMACEU | RYTM | 0.78% |
| ASCENDIS PHA-ADR | ASND | 0.76% |
| ADMA BIOLOGICS INC | ADMA | 0.70% |
| KYMERA THERAPEUTICS INC | KYMR | 0.69% |
| ARCUTIS BIOTHERAPEUTICS I | ARQT | 0.69% |
| VIKING THERAPEUTICS INC | VKTX | 0.68% |
| ACADIA PHARMACEUTICALS IN | ACAD | 0.68% |
| LEGEND BIOTECH CORP-ADR | LEGN | 0.66% |
| CELCUITY INC | CELC | 0.65% |
| MADRIGAL PHARMAC | MDGL | 0.65% |
| BEAM THERAPEUTICS INC | BEAM | 0.64% |
| VERACYTE INC | VCYT | 0.64% |
| LIQUIDIA CORP | LQDA | 0.63% |
| APELLIS PHARMACE | APLS | 0.60% |
| NUVALENT INC-A | NUVL | 0.59% |
| TRAVERE THERAPEUTICS INC | TVTX | 0.59% |
| INTELLIA THERAPE | NTLA | 0.57% |
| KRYSTAL BIOTECH INC | KRYS | 0.57% |
| SAREPTA THERAPEU | SRPT | 0.52% |
| SOLENO THERAPEUTICS INC | SLNO | 0.51% |
| RECURSION PHARMACEUTICALS | RXRX | 0.50% |
| SUMMIT THERAPEUTICS INC | SMMT | 0.48% |
| ARCELLX INC | ACLX | 0.45% |
| ULTRAGENYX PHARM | RARE | 0.44% |
| GRAIL INC | GRAL | 0.41% |
| Other (Cash, derivatives and other liabilities) | 0.31% | |
| Total: | ||
Read a prospectus and summary prospectus (if available) carefully before investing. It contains the investment objective, risks charges, expenses and the other information, which should be considered carefully before investing. To obtain a prospectus and summary prospectus (if available) click here or call 800.820.0888.
Investing involves risk, including the possible loss of principal.
Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Wealth Solutions, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Private Investments, LLC.
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