| Security Name | Ticker | % of Net Assets |
|---|---|---|
| ABBVIE INC | ABBV | 8.31% |
| AMGEN INC. | AMGN | 5.59% |
| VERTEX PHARMACEUTICALS | VRTX | 4.99% |
| GILEAD SCIENCES, INC. | GILD | 4.90% |
| REGENERON PHARMACEUTICALS | REGN | 3.98% |
| ALNYLAM PHARMACEUTICALS | ALNY | 3.22% |
| INSMED INC | INSM | 3.02% |
| NATERA INC | NTRA | 2.54% |
| ASTRAZENECA PLC ADR | AZN | 2.49% |
| BEONE MEDICINES LTD-ADR | BGNE | 2.32% |
| BIOGEN IDEC, INC. | BIIB | 2.30% |
| UNITED THERAPEUTICS CORP | UTHR | 2.14% |
| ROYALTY PHARMA PLC- CL A | RPRX | 2.05% |
| ILLUMINA INC | ILMN | 2.00% |
| EXACT SCIENCES | EXAS | 2.00% |
| INCYTE CORP | INCY | 1.84% |
| NEUROCRINE BIOSCIENCES IN | NBIX | 1.74% |
| REVOLUTION MEDICINES INC | RVMD | 1.71% |
| VIATRIS INC | VTRS | 1.67% |
| BRIDGEBIO PHARMA INC | BBIO | 1.66% |
| ARGENX SE - ADR | ARGX | 1.63% |
| GUARDANT HEALTH INC | GH | 1.61% |
| IONIS PHARMACEUTICALS, IN | IONS | 1.60% |
| MODERNA INC | MRNA | 1.51% |
| JAZZ PHARMACEUTICALS PLC | JAZZ | 1.51% |
| EXELIXIS, INC. | EXEL | 1.51% |
| AVIDITY BIOSCIENCES INC | RNA | 1.48% |
| ROIVANT SCIENCES LTD | ROIV | 1.45% |
| BIOMARIN PHARMACEUTICAL | BMRN | 1.42% |
| CRISPR THERAPEUTICS AG | CRSP | 1.37% |
| MEDPACE HOLDINGS | MEDP | 1.32% |
| HALOZYME THERAPEUTICS INC | HALO | 1.29% |
| CYTOKINETICS INC | CYTK | 1.28% |
| ALKERMES PLC | ALKS | 1.26% |
| ARROWHEAD PHARMACEUTICALS | ARWR | 1.26% |
| BIONTECH SE-ADR | BNTX | 1.21% |
| CIDARA THERAPEUTICS INC | CDTX | 1.13% |
| MERUS NV | MRUS | 1.13% |
| PTC THERAPEUTICS | PTCT | 1.11% |
| PROTAGONIST THER | PTGX | 1.08% |
| VAXCYTE INC | PCVX | 1.07% |
| RHYTHM PHARMACEU | RYTM | 0.96% |
| TG THERAPEUTICS | TGTX | 0.95% |
| MADRIGAL PHARMAC | MDGL | 0.94% |
| ADMA BIOLOGICS INC | ADMA | 0.93% |
| AXSOME THERAPEUT | AXSM | 0.90% |
| LEGEND BIOTECH CORP-ADR | LEGN | 0.89% |
| VIKING THERAPEUTICS INC | VKTX | 0.89% |
| AMICUS THERAPEUTICS INC | FOLD | 0.88% |
| VERACYTE INC | VCYT | 0.86% |
| SCHOLAR ROCK HOLDING CORP | SRRK | 0.86% |
| ACADIA PHARMACEUTICALS IN | ACAD | 0.85% |
| TRAVERE THERAPEUTICS INC | TVTX | 0.82% |
| ASCENDIS PHA-ADR | ASND | 0.80% |
| ARCUTIS BIOTHERAPEUTICS I | ARQT | 0.80% |
| ULTRAGENYX PHARM | RARE | 0.79% |
| KYMERA THERAPEUTICS INC | KYMR | 0.77% |
| APELLIS PHARMACE | APLS | 0.76% |
| SOLENO THERAPEUTICS INC | SLNO | 0.73% |
| LIQUIDIA CORP | LQDA | 0.72% |
| SAREPTA THERAPEU | SRPT | 0.71% |
| BEAM THERAPEUTICS INC | BEAM | 0.70% |
| CELCUITY INC | CELC | 0.70% |
| NUVALENT INC-A | NUVL | 0.67% |
| RECURSION PHARMACEUTICALS | RXRX | 0.65% |
| TWIST BIOSCIENCE CORP | TWST | 0.62% |
| SUMMIT THERAPEUTICS INC | SMMT | 0.60% |
| MIRUM PHARMACEUTICALS INC | MIRM | 0.59% |
| KRYSTAL BIOTECH INC | KRYS | 0.59% |
| ARCELLX INC | ACLX | 0.51% |
| INTELLIA THERAPE | NTLA | 0.46% |
| GRAIL INC | GRAL | 0.40% |
| Total: | ||
Read a prospectus and summary prospectus (if available) carefully before investing. It contains the investment objective, risks charges, expenses and the other information, which should be considered carefully before investing. To obtain a prospectus and summary prospectus (if available) click here or call 800.820.0888.
Investing involves risk, including the possible loss of principal.
Guggenheim Investments represents the following affiliated investment management businesses of Guggenheim Partners, LLC: Guggenheim Partners Investment Management, LLC, Security Investors, LLC, Guggenheim Funds Distributors, LLC, Guggenheim Funds Investment Advisors, LLC, Guggenheim Corporate Funding, LLC, Guggenheim Wealth Solutions, LLC, Guggenheim Partners Europe Limited, Guggenheim Partners Japan Limited, GS GAMMA Advisors, LLC, and Guggenheim Private Investments, LLC.
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